AMPK activator SC4 ( SC-4; SC 4; SC4 )

Catalog No. M11503 CAS No. 1364692-88-5

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Product Name

AMPK activator SC4
Note

Research use only, not for human use.
Brief Description

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3.
Description

AMPK activator SC4 is a potent, specific activator of α2β2-AMPK complexes with EC50 of 17.2 and 82.1 nM for α2β2γ1 and α2β2γ3, the predominant AMPK isoform complexes in human skeletal muscle; does not significantly stimulate activities of the α1-equivalent complexes α1β2γ1 and α1β2γ3 at 5 uM; Deletion β-subunit carbohydrate binding module (CBM) abolished SC4 activation; preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
Synonyms

SC-4; SC 4; SC4
Pathway

Membrane Transporter/Ion Channel
Target

AMPK
Recptor

AMPK
Research Area

——
Indication

——

CAS Number

1364692-88-5
Formula Weight

471.90
Molecular Formula

C26H18ClN3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC=C(C5=CC=CC=C5O)C=C4)N=C3N2)=CC=C1C
Chemical Name

5-((6-Chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-3Himidazo[4,5-b]pyridin-2-yl)oxy)-2-methylbenzoic acid

1. Ngoei KRW, et al. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9.

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